CLINICAL TRIALS

The SAGA Clinical Trials Center has numerous open clinical studies and is currently enrolling patients with cancer in adults over 18 years of age.

LUNG

NameDescriptionView studyPatologhy
TROPION-Lung08Dato-DXd Plus Study of Pembrolizumab versus Pembrolizumab alone in the first-line treatment of subjects with advanced or metastatic NSCLC without actionable genomic alterations (TROPION-Lung08)Ver EstudioLung cancer
MK1084-001Phase 1, multicenter, open-label study to evaluate the safety, tolerability, pharmacokinetics, and efficacy of MK-1084 as monotherapy and in combination with pembrolizumab in subjects with advanced KRAS G12C mutant solid tumorsVer EstudioLung, Colon, Pancreas Cancer
MK2870-004Phase 3, randomized, open-label study of MK 2870 versus chemotherapy (docetaxel or pemetrexed) in previously treated advanced or metastatic non-squamous non-small cell lung cancer (NSCLC) with EGFR mutations or other genomic alterations.Ver EstudioLung cancer
TAS6417-301Safety and efficacy study of TAS6417 (zipalertinib) in combination with standard chemotherapy for non-small cell lung cancer with EGFR exon 20 insertion mutations.Ver EstudioLung cancer
MK3475-01HKEYMAKER-U01 Phase I/II Umbrella study of novel conjugated treatments in patients with previously treated stage IV non-small cell lung cancer.Ver EstudioLung cancer
MK3475-01GKEYMAKER-U01 Phase 2 umbrella study with rotating cohorts of investigational agents in combination with pembrolizumab, with or without platinum-based chemotherapy, in treatment-naïve participants with stage IV non-small cell lung cancer (NSCLC)Ver EstudioLung cancer
MK3475-01IKEYMAKER-U01 – 01 I Phase 2 umbrella study in previously treated participants with stage IV squamous non-small cell lung cancer (NSCLC)Ver EstudioLung cancer

Multitumoral

NameDescriptionView studyPatologhy
MK1XXX-001

The purpose of this study is to investigate the pharmacokinetic efficacy and safety of MK-1XXX in patients with solid tumors with KRASG12C mutation, in first or second line of treatment. Amendment 4 (Lung, Colon (2L), Ovary, Pancreas)

Ver EstudioTúmores sólidos

Solid Tumor

NameDescriptionView studyPatologhy
MK0472-001Phase I-Ib open-label study of MK-0472 monotherapy and in combination with Pembrolizumab in patients with advanced/metastatic solid tumorsVer EstudioSolid tumors

Gastric or gastroesophageal junction cancer

NameDescriptionView studyPatologhy
Destiny-Gastric05Multicenter, randomized, open-label, phase 3 trial of trastuzumab deruxtecan (Enhertu®) plus chemotherapy plus or minus pembrolizumab versus chemotherapy plus trastuzumab plus or minus pembrolizumab as first-line treatment in participants with HER2-positive unresectable or locally advanced or metastatic gastric or gastroesophageal junction cancer (Destiny-Gastric05).Ver EstudioGastric or gastroesophageal junction cancer.

Prostate cancer

NameDescriptionView studyPathology
MEVPRO-2Phase 3 randomized, double-blind, placebo-controlled study of PF 06821497 (Mevrometostat) with Enzalutamide in castration-resistant stage IV prostate cancerVer EstudioProstate cancer
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